STUDI LITERATUR POTENSI ANTIOKSIDAN DAUN KELOR (MORINGA OLEIFERA L.) TERHADAP HIPERKOLESTEROLEMIA.

  • Desry Natalia Sidauruk Universitas Negeri Medan
  • Lamtama Robintang Simarmata Universitas Negeri Medan
  • Dian Sharon Simbolon Universitas Negeri Medan
  • Jessica Angelita Lubis Universitas Negeri Medan
  • Renny Cherly Cicilia Sitorus Universitas Negeri Medan
Keywords: Moringa oleifera, Moringa leaves, antioxidants, hypercholesterolemia, cholesterol

Abstract

Hypercholesterolemia is a lipid metabolism disorder characterized by elevated blood cholesterol levels and is a risk factor for cardiovascular disease. Moringa leaves (Moringa oleifera L.) are known to contain various bioactive compounds that have the potential to act as natural antioxidants and play a role in controlling cholesterol levels. This study aims to examine the antioxidant compounds contained in Moringa leaves and their potential in the prevention and management of hypercholesterolemia, based on various published research results. The method used was a literature review by collecting and analyzing relevant scientific articles. The results of the study indicate that Moringa leaves contain flavonoids, polyphenols, quercetin, kaempferol, gallic acid, vitamin C, β-carotene, saponins, and phytosterols, which act as antioxidants. These compounds can inhibit free radical formation, prevent LDL oxidation, enhance the endogenous antioxidant system, and help improve lipid profiles by reducing total and LDL cholesterol levels and increasing HDL levels. Based on the results of this study, Moringa leaves have the potential to be developed as an herbal alternative in the prevention and management of hypercholesterolemia.

References

Agustin, R. A., Fahdhienie, F., & Septiani, R. (2024). Analisis Faktor Risiko Kejadian Hiperkolesterolemia Pada Masyarakat Desa Pulau Baguk Kecamatan Pulau Banyak Kabupaten Aceh Singkil. Jurnal Promotif Preventif, 7(5), 1030-1041. https://doi.org/10.47650/jpp.v7i5.1474

Alia, F., Putri, M., Anggraeni, N., & Syamsunarno, M. R. A. A. (2022). The potency of Moringa oleifera Lam. as protective agent in cardiac damage and vascular dysfunction. Frontiers in Pharmacology, 12, Article 724439. https://doi.org/10.3389/fphar.2021.724439

Amin, S., & Lidiasari, A. L. (2025). Analisis senyawa bioaktif daun kelor (Moringa oleifera L.) sebagai agen hipokolesterolemik potensial. Journal of Public Health Science, 2(2), 166-171. https://doi.org/10.70248/jophs.v2i2.2210

Anggraini, D., Abdurahman, M. S. A., & Sandy, N. S. S. (n.d.). K for K (Kelor for anti-Kolesterol: Kajian mengenai konsumsi daun kelor sebagai penghambat sintesis kolesterol dalam upaya pencegahan batu empedu). SCRIPTA SCORE Scientific Medical Journal.

Asisi, N., Uliyah, U., Amaliyah, N. F., & Hasrawati, A. (2021). Aktivitas antioksidan ekstrak daun kelor (Moringa oleifera L.) dan pengembangannya menjadi bentuk sediaan gel. As-Syifaa Jurnal Farmasi, 13(1), 1-6. https://doi.org/10.56711/jifa.v13i1.757

Charolina, Agustina, C., Rahmawati, D. S., Novita, D., Aningrum, E. D., Kusmayanti, E., Oktaviani, E. T., Syahida, F. H., Azfa, F. M., & Rhamadianto, M. I. (2025). Review artikel: Studi in silico molecular docking senyawa bahan alam terhadap HMG-CoA reduktase sebagai target terapi penurunan kolesterol. Jurnal Penelitian Farmasi Indonesia, 14(1), 1–9. https://doi.org/10.51887/jpfi.v14i1.2066

Dwitiyanti, Sunaryo, H., & Kania, I. R. (2015). Uji aktivitas antihiperkolesterolemia fraksi etil asetat ekstrak daun kelor (Moringa oleifera Lam.) terhadap kadar kolesterol total dan LDL kolesterol pada hamster hiperkolesterolemia. PHARMACY: Jurnal Farmasi Indonesia, 12(02), 153–154.

Fitriana, W. D., Ersam, T., Shimizu, K., & Fatmawati, S. (2016). Antioxidant activity of Moringa oleifera extracts. Indonesian Journal of Chemistry, 16(3), 297-301. https://doi.org/10.22146/ijc.21145

Harefa, Y. S., & Yulianti. (2023). Studi in vitro potensi antioksidan dan aktivitas antidiabetes fraksi etil asetat buah parijoto (Medinilla speciosa B.). Journal Health of Education, 4(1).

Layreinshia, B., & Atzmardina, Z. (2024). Edukasi mengenai makanan sehat untuk menanggulangi hiperkolesterolemia pada masyarakat Desa Cikupa. Syntax Literate: Jurnal Ilmiah Indonesia, 9(1), 369–373. https://doi.org/10.36418/syntaxliterate.v9i1.14843

Mahmudah, R., Himaniarwati, H., & Imran, S. A. A. (2024). Standarisasi dan Uji Aktivitas Antikolesterol Ekstrak Etanol Daun Labu Kuning (Cucurbita moschata Duch.) pada Mencit (Mus musculus). Jurnal Mandala Pharmacon Indonesia, 10(1), 111-121. https://doi.org/10.35311/jmpi.v10i1.486

Manurung, B. L., Monica, E., & Rollando, R. (2023). Formulasi dan evaluasi antioksidan daun kelor Moringa oleifer L dalam sediaan serum dengan metode senyawa radikal DPPH. Sainsbertek Jurnal Ilmiah Sains & Teknologi, 3(2), 66-77. https://doi.org/10.33479/sb.v3i2.233

Marhaeni, L. S. (2021). Daun kelor (Moringa oleifera) sebagai sumber pangan fungsional dan antioksidan. AGRISIA: Jurnal Ilmu-Ilmu Pertanian, 13(2).

Marumata, C. V., Woda, R. R., & Artawan, I. M. (2019). Pengaruh Pemberian Jus Daun Kelor (Moringa Oleifera Lam) Terhadap Kadar Kolesterol Total Orang Dewasa Hiperkolesterolemia Di Wilayah Kerja Puskesmas Oebobo Kota Kupang. Cendana Medical Journal, 7(2), 325-334. https://doi.org/10.35508/cmj.v7i2.1806

Muna, L. (2022). Aktivitas antioksidan ekstrak air daun kelor (Moringa oleifera) dengan metode DPPH serta analisis kualitatif kandungan metabolit sekunder. Sasambo Journal Mahmudah, R., Himaniarwati, H., & Imran, S. A. A. (2024). Standarisasi dan Uji Aktivitas Antikolesterol Ekstrak Etanol Daun Labu Kuning (Cucurbita moschata Duch.) pada Mencit (Mus musculus). Jurnal Mandala Pharmacon Indonesia, 10(1), 111-121. https://doi.org/10.35311/jmpi.v10i1.486

Nadhira, A. N., Nurwati, I., & Budiani, D. R. (2023). Efek ekstrak etanolik daun kelor terhadap kadar HDL, kadar LDL, serta ketebalan aorta tikus wistar model sindrom metabolik. Plexus Medical Journal, 2(1), 1–8. https://doi.org/10.20961/plexus.v2i1.219

Nughraheni, O. D., Dwihestie, L. K., ST, S., Daryanti, M. S., & ST, S. (2020). Literatur Review Pengaruh Pendidikan Kesehatan Terhadap Pengetahuan Perilaku Hidup Bersih Dan Sehat Anak. http://digilib.unisayogya.ac.id/id/eprint/5259

Nuranjumi, N., & Wijaya, J. I. (2022). Penatalaksanaan Ny. M Usia 58 Tahun dengan Hiperkolesterolemia melalui Pendekatan Dokter Keluarga. Jurnal Penelitian Perawat Profesional, 4(1), 257-270. https://doi.org/10.37287/jppp.v4i1

Pareek, A., Pant, M., Gupta, M. M., Kashania, P., Ratan, Y., Jain, V., Pareek, A., & Chuturgoon, A. A. (2023). Moringa oleifera: An updated comprehensive review of its pharmacological activities, ethnomedicinal, phytopharmaceutical formulation, clinical, phytochemical, and toxicological aspects. International Journal of Molecular Sciences, 24(3). https://doi.org/10.3390/ijms24032098

Peñalver, R., Martínez-Zamora, L., Lorenzo, J. M., Ros, G., & Nieto, G. (2022). Nutritional and antioxidant properties of Moringa oleifera leaves in functional foods. Foods, 11(8), 1107. https://doi.org/10.3390/foods11081107

Sabreen, S., Curie, D., Babu, J. A., Gopi, M. V., Manoj, Y. J., Billgates, T., Meiti, T. S., & Thangabalan, B. (2026). A review article of an antioxidant activity of Moringa oleifera leaf. International Journal of Pharmaceutical Sciences, 4(3), 1168–1182. https://doi.org/10.5281/zenodo.18976557

Safitri, S., Mappahya, A. A., & Safitri, A. (2023). Hubungan Faktor Risiko dengan Kejadian Hiperkolesterolemia Pasien Rawat Jalan Penderita Jantung Koroner di RS Ibnu Sina Makassar Tahun 2021. Fakumi Medical Journal: Jurnal Mahasiswa Kedokteran, 3(8), 552-562. https://doi.org/10.33096/fmj.v3i8.257

Satriyani, D. P. P. (2021). Review artikel: Aktivitas antioksidan ekstrak daun kelor (Moringa oleifera Lam.). Jurnal Farmasi Malahayati, 4(1), 31-43.

Tinggi, D. A. N. K. (2025). Tepung pedada: Solusi alami untuk diabetes (Issue July).

Tjong, A., Assa, Y. A., & Purwanto, D. S. (2021). Kandungan antioksidan pada daun kelor (Moringa oleifera) dan potensi sebagai penurun kadar kolesterol darah. eBiomedik, 9(2), 248–254. https://doi.org/10.35790/ebm.v9i2.33452

Yamin, W., Kamumu, I., & Kasim, Z. (2025). Aktivitas antioksidan kombinasi ekstrak daun kelor (Moringa oleifera L.) dan kulit buah naga (Hylocereus polyrhizus): Kajian in vivo pada mencit hiperkolesterol. Majalah Farmaseutik, 21(3), 341–347. https://doi.org/10.22146/farmaseutik.v21i3.107398

Zhang, Q., Yang, W., Liu, J., Liu, H., Lv, Z., Zhang, C., Chen, D., & Jiao, Z. (2020). Identification of six flavonoids as novel cellular antioxidants and their structure activity relationship. Oxidative Medicine and Cellular Longevity, 2020. https://doi.org/10.1155/2020/4150897

Published
2026-06-18
How to Cite
Natalia Sidauruk, D., Robintang Simarmata, L., Sharon Simbolon, D., Angelita Lubis, J., & Cherly Cicilia Sitorus, R. (2026). STUDI LITERATUR POTENSI ANTIOKSIDAN DAUN KELOR (MORINGA OLEIFERA L.) TERHADAP HIPERKOLESTEROLEMIA. Didaktik : Jurnal Ilmiah PGSD STKIP Subang, 12(02), 150 - 163. https://doi.org/10.36989/didaktik.v12i02.14970

Most read articles by the same author(s)